Solving Protein Structures to Uncover Molecular Mechanisms of Cancer

Equipping and staffing a state-of-the-art facility to solve the atomic-level structure of cancer-relevant proteins

Full Project Name:Solving Protein Structures to Uncover Molecular Mechanisms of CancerPrimary Academic Partner:Gustavo Leone, PhDPrincipal Investigator:Gustavo Leone, PhDCo-Investigator:Wei Lui, PhD, Pharmacology and ToxicologyAward Amount:5500000

Award Date

July2022

Project Duration:96

Project Updates:

Completed installation of Bruker imaging MS systems for spatial omics analysis in the facility space
Supported 12 projects to date through the protein production facility for MCW researchers with diverse research foci ranging from combating viral and parasitic infections, enhancing cancer patient outcomes, and improving treatment for patients with ischemic heart disease
Opened the cryo-EM facility for testing in fall of 2024 and supported the collection of preliminary data for nine different investigators to support their grant submissions or resubmissions
Hosted a symposium to highlight the critical role of cryo-EM in accelerating drug discovery with nearly 100 attendees