Role of the Brain Renin Angiotensin System in Neuroinflammation

Project Updates:

• Concluded that the prorenin receptor is involved in multiple cellular processes, including regulation of the brain RAS and neuroinflammation, based on the project studies, which has the opportunity to contribute to the development of therapies for salt-sensitive hypertension, a prevalent condition among the 50% of Wisconsin's population over 50 that has hypertension
• Resulted in three publications and three national and international presentations
• Continuing to breed mouse models to test hypotheses related to signaling suppression of the inflammatory response in the brain
• Leveraged over $230,000 from the American Heart Association
• Conducted six presentations and seven publications to disseminate project findings