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Pediatric Lung Research Program

Identifying causes of pediatric lung disease to identify new therapies and outreach strategies for Wisconsin children

Full Project Name:Pediatric Lung Research Program to Optimize the Respiratory Health of Children in WisconsinPrincipal Investigator:G. Ganesh Konduri, MD, PediatricsCo-Investigator(s):Joanne Lagatta, MD, Pediatrics
Amy Pan, PhD, Pedatrics
Award Amount:$1,500,000
Award Date
October2021
Project Duration:60 months

Project Summary:


Lung disease is the most common reason for infants and children to require medical care, including intensive care support at birth, as well as medical care in early childhood. The leading causes of neonatal repiratory failure are persistence of pulmonary hypertension and premature birth leading to bronchopulmonary dysplasia. These illnesses affect 10,000 newborn infants in Wisconsin every year.

In addition, lung injury or disease can impose lifelong breathing difficulty, hospital visits, and neurodevelopmental delays. Over 200,000 Wisconsin children and adults under age 40 are affected by conditions of neonatal lung disease. Improving the respiratory health of Wisconsin children requires further investigation on its causes and contributing factors in order to develop new therapies that may decrease complications of these diseases.

Through this award, investigators will aim to identify causes of pediatric lung disease to inform future therapies and outreach strategies that will improve the respiratory health of Wisconsin children.

Project Updates:


  • Uncovered a novel mechanism related to the energy producing system inside cells that will enable the development of new therapies to improve the growth of new blood vessels in the lungs injured by premature birth
  • Conducting preclinical studies to repurpose an approved drug for bronchopulmonary dysplasia to improve lung growth in disease modals
  • Completed a quality improvement program for preterm infants with bronchopulmonary dysplasia leading to reduced home oxygen therapy duration
  • Developed a fully integrated team of research scientists, data analysts, and collaborators
  • Leveraged funding to obtain an NIH award to investigate the mechanisms of bronchopulmonary dysplasia

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