Developing statistical methods for optimal CRI identification for MDS patients
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Myelodysplastic Syndromes (MDS) are a group of diverse bone marrow disorders in which the bone marrow does not produce enough healthy blood cells. MDS primarily affects patients over 60 years of age, but can affect younger patients as well.
To treat MDS, the optimal conditioning regimen intensity (CRI) must be identified. This requires serious consideration of the characteristics of the individual patients with MDS. To accomplish the identification of a therapy regimen that uses less intense chemotherapy and radiation to control the disease, but decreases treatment-related mortality without increasing relapse, the research team will aim to develop statistical methods to find a rule that assigns the optimal CRI to each patient.
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