Chromatin Remodeling Mediated by Insulin Signaling: The Role of FoxK Factors

Project Description Narrative:

In 2023, 406,445 people in Wisconsin, or 8.8% of the adult population, have diagnosed diabetes. An additional 1.5 million people in Wisconsin, or 34% of the adult population, have pre-diabetes with blood glucose levels that are higher than normal but not yet high enough to be diagnosed with diabetes. Diabetes costs an estimated $5.5 billion in Wisconsin each year. The serious complications include heart disease, stroke, amputation, end-stage kidney disease, blindness, and death. A primary driver of diabetic complications and deaths stems from the disruption in maintaining balanced glucose levels.

This project aims to investigate essential chromatin remodeling events driving transcriptional regulation of glucose production in hepatocytes. Improving our understanding of the complex mechanisms governing this crucial process will enable the advancement of diabetes therapies and treatments needed to improve the lives of people in Wisconsin