Cellular Functions of a Nuclear FKBP: A Drug Receptor Becoming a Chromosome-Specific Necleosome Assembler

Project Description Narrative:

Through investigating the cellular functions of Fpr4—an immunophilin-related nuclear FKBP (FK506 binding protein) possessing a novel histone chaperone activity—the researchers seek to clarify whether nuclear FKBPs play key roles in the assembly and maintenance of chromatin structure. Further, the investigators will explore whether Fpr4 impacts the structure of chromosome IX specifically, determining whether that chromatin structure may be modulated by regulatory factors such as Fpr4 on a chromosome-specific basis. The long-term goal of this project is to establish a new research direction in cancer biology, and to obtain federal funding to sustain a research base at MCW that maintains a leadership role in this line of investigation. The outcome of this research will enhance the understanding of the genetic and molecular basis of cancer, leading to more efficient prevention of and better treatment of cancer.