Project Description Narrative:

Cardiovascular, renal, metabolic, and respiratory diseases significantly impact many Wisconsin residents. Conditions such as high blood pressure, heart attacks, kidney disease, and asthma are common in our state and often underdiagnosed, leading to severe health consequences. Additionally, obesity, pre-eclampsia, and cancer worsen these challenges, highlighting an urgent need for advanced research.

This project will use spatial transcriptomics to study gene activity in diseased tissues. The innovative Xenium Profiler technology will allow researchers to analyze gene expression and cell communication within complex tissues like the heart and brain. By investigating these relationships, researchers hope to learn more about the mechanisms behind these diseases and develop targeted treatments.

This project will support research faculty in MCW’s Department of Physiology, fostering collaboration and advancing health research. Ultimately, this project aims to improve the health of Wisconsin residents by laying foundations for new treatments and interventions.