Vascular Endothelial Redox Stress Mediated by Acrolein

Project Description Narrative:

Cardiovascular disease is a major cause of premature death and morbidity in Wisconsin. Atherosclerosis, the buildup of fats, cholesterol, and other substances on artery walls, is common in cardiovascular disease, and can have systemic effects that also affect the brain, kidneys, and circulation. The dysfunction of endothelial cells, cells that line the interior surface of blood vessels, can cause atherosclerosis.

Through this award, investigators aim to study how of acrolein, a common environmental pollutant produced by car exhaust and cigarette smoke, can damage endothelial cells.