Understanding the effect of a common environmental pollutant on the devleopment and prevention of cardiovascular disease in Wisconsin
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Examined the effects of acrolein on thioredoxin reductase (TrxR) which is essential for cell growth and survival
Discovered that acrolein irreversibly inhibits TrxR activity in endothelial cells. Widespread downstream effects that promote endothelial cell death are expected from this inhibition
Disseminated findings via a poster presentation and published two scientific papers
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