Advancing understanding of how abnormal events in the brain during embryogenesis contribute to Autism Spectrum Disorder
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An increasing number of children are being diagnosed with autism spectrum disorder (ASD), a developmental disorder that results in a wide range of behavioral, intellectual, and social disabilities. ASD is caused by a group of neurodevelopmental disorders that arise from abnormal development of the brain during embryogenesis. Understanding the factors that promote normal neurodevelopment and identifying new approaches to prevent or correct neurodevelopmental abnormalities may provide new therapeutic strategies for ASD.
Through this award, investigators will aim to advance understanding of how abnormal events that occur during brain development contribute to ASD by testing whether a new group of compounds can be used to decrease the occurrence of abnormal events in the brain.
Detected that the study protein, SmgGDS, undergoes changes as neurons develop
Confirmed that SmgGDS can be altered in developing neurons using experimental agents, which will be valuable tools for examining how manipulation of SmgGDS alters neuronal maturation
Working to improve the techniques needed to analyze the prenylome in the brain
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