Regulating Small GTPase Prenylome by SmgGDS During Neuronal Development

Advancing understanding of how abnormal events in the brain during embryogenesis contribute to Autism Spectrum Disorder

Full Project Name:Regulation of the Small GTPase Prenylome by SngGDS During Neuronal DevelopmentPrincipal Investigator:Carol Williams, PhD, Pharmacology and Toxicology Co-Investigator:Allison Ebert, PhD, Cell Biology, Neurobiology, and Anatomy; Cecilia J. Hillard, PhD, Pharmacology and Toxicology; Mark Distefano, PhD, University of Minnesota Award Amount:$250,000
Award Date
July2021
Project Duration:24 months

Project Description Narrative:


An increasing number of children are being diagnosed with autism spectrum disorder (ASD), a developmental disorder that results in a wide range of behavioral, intellectual, and social disabilities. ASD is caused by a group of neurodevelopmental disorders that arise from abnormal development of the brain during embryogenesis. Understanding the factors that promote normal neurodevelopment and identifying new approaches to prevent or correct neurodevelopmental abnormalities may provide new therapeutic strategies for ASD.

Through this award, investigators will aim to advance understanding of how abnormal events that occur during brain development contribute to ASD by testing whether a new group of compounds can be used to decrease the occurrence of abnormal events in the brain.

Project Updates:


Project has not yet entered reporting period.

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