Developing a PDX breast cancer library to serve as platform for patient-specific hypotheses related to personalized treatment strategies
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Established that the humanized prolactin NSG mouse is a novel and superior host for patient-derived breast cancer zenografts, which is a paradigm shifting research tool that enables the study of all subtypes of breast cancer that was previously unattainable
A total of 15 therapy resistant metastatic breast cancer PDX models were sequenced
Multiple novel therapeutic targets have been identified for validation in future studies
Through this study, the researchers gained new and important insight into the underlying drivers of therapy resistance in breast cancer that will help the development of more effective strategies for treatment
Published three manuscripts in cancer and bioinformatic journals
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