Optimal Conditioning Regimen Intensity for Myelodysplastic Syndromes

Developing statistical methods for optimal CRI identification for MDS patients

Full Project Name:Optimal Conditioning Regimen Intensity for Competing Risks Data in Myelodysplastic SyndromesPrincipal Investigator:Kwang W. Ahn, PhD, Institute for Health and EquityCo-Investigator:Soyoung Kim, PhD, Institute for Health and Equity; Wael Saber, MD, MS, MedicineAward Amount:$200,000
Award Date
January2018
Project Duration:24 months

Project Description Narrative:


Myelodysplastic Syndromes (MDS) are a group of diverse bone marrow disorders in which the bone marrow does not produce enough healthy blood cells. MDS primarily affects patients over 60 years of age, but can affect younger patients as well.

To treat MDS, the optimal conditioning regimen intensity (CRI) must be identified. This requires serious consideration of the characteristics of the individual patients with MDS. To accomplish the identification of a therapy regimen that uses less intense chemotherapy and radiation to control the disease, but decreases treatment-related mortality without increasing relapse, the research team will aim to develop statistical methods to find a rule that assigns the optimal CRI to each patient.

Project Updates:


Project has not yet entered reporting period

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