Understanding obesity's role in the development of type 2 diabetes
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Discovered that a key enzyme plays a significant role in protecting insulin-producing cells in the pancreas by preventing an accumulation of free fatty acids. If free fatty acids build up to significant levels, the resulting chemical environment can become toxic and even deadly to the cell
Identified the feasibility, reproducibility, and sensitivity of a targeted mass spectrometry approach for the detection of a low abundant protein (i.e., PPT1) in human biopsied tissues
Demonstrated that PPT1 levels are higher in adipose tissues from metabolically healthy non-obese and obese individuals compared to diabetic obese individuals. A similar trend was observed for another lysosomal protein, LAMP1
Identified results that support a novel role of the lysosome and its degradative enzyme, PPT1, in protecting individuals from developing Type 2 Diabetes
Generated new knowledge about how certain fatty acids harm insulin-producing cells, as well as about the enzyme that maintains a healthy level of fatty acids, the investigators will be better able to design new approaches to delay or prevent the onset of type 2 diabetes due to obesity
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