A Healthier Wisconsin

Innovative Approaches to Precision Medicine (IAPM) 2.0

Developing precision prevention and treatment for hypertension using multi-omics analysis

Full Project Name:Innovative Approaches to Precision Medicine (IAPM) 2.0Principal Investigator:Mingyu Liang, MB, PhD, PhysiologyAward Amount:$1,000,000
Award Date
Project Duration:60 months

Project Description Narrative:

Hypertension affects approximately 45% of adults in the United States, with the prevalence of the disease in Wisconsin tracking closely with this national figure. Hypertension substantially increases the risk of heart disease, stroke, and chronic kidney disease, all leading causes of death and significant burdens on the state's healthcare system.

Understanding the molecular mechanisms underlying blood pressure regulation and hypertension-induced organ damage and utilizing this mechanistic understanding to develop precision prevention and treatment will broadly impact health, including the health of nearly half of Wisconsin residents. Multi-omics analysis refers to the analysis of the genome (all DNA sequences in an organism) and various levels of regulation and manifestation of the function of the genome. Multi-omics analysis has transformed biomedical research. However, a widely recognized limitation of many multi-omics resources is the lack of disease-specific information.

This project aims to develop a multi-omics resource called HyperExpress, to enable transformative advances in the entire field of hypertension and related end organ damage research and to utilize HyperExpress to discover novel mechanisms underlying hypertension and related end organ damage and validate these mechanisms.

Outcomes & Lessons Learned:

  • Obtained and began analyzing several sets of omics data from animal models and patient samples
  • Findings provide new insights into how the hypothalamus may be involved in the development of hypertension under different disease conditions and provide a cell landscape of advanced hypertensive CKD in humans, shedding light on the cellular and molecular basis of the disease

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