Collaborative Research into the Etiology and Treatment of Pediatric and Congenital Heart Disease

Developing a pediatric and congenital heart disease research program to develop new treatment strategies and train the next generation of cardiovascular scientists

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Full Project Name:Collaborative Research into the Etiology and Treatment of Pediatric and Congenital Heart DiseasePrincipal Investigator:Joy Lincoln, PhD, FAHA, PediatricsAward Amount:$3,000,000

Award Date

July2019

Project Duration:66 months

Project Description Narrative:

Cardiovascular disease is the number one cause of death in the United States. The national age-adjusted death rate due to cardiovascular disease is 165 per 100,000 individuals. Wisconsin’s rate is 25th in the nation, with 158 cardiovascular deaths per 100,000 individuals.

Congenital cardiovascular defects are structural problems that develop in the heart or the surrounding blood vessels prior to birth. Also known as congenital heart disease, such malformations are the most common birth defect with an incidence of ~1/100 live births. Despite the high prevalence of congenital heart disease, comparatively little is known about its causes. The majority of children affected by these diseases survive well into adulthood, but deal with residual issues that significantly effect quality of life. Growing evidence suggests that adult survivors of congenital heart disease develop “adult” cardiovascular conditions at younger ages and in more aggressive forms than those born with structurally normal hearts. The reason for this accelerated course is not known. Through this award, this project will develop a cardiovascular research program at MCW focused on congenital heart disease.

The program will develop a well-trained and highly skilled workforce that will increase the capacity to provide cardiac care in Wisconsin and generate new knowledge that will lead to improved treatments for heart disease.

Project Updates:

Recruited Dr. Lincoln to serve as director of cardiovascular research. Dr. LaDisa who continues to proliferatively publish and submit extramural grant applications, and Dr. Han who has since recruited a team to grow her lab and has been highly successful in securing extramural funding based on preliminary data stemming from this award
Re-launched the seminar series to leverage the research, quality, and education within the Herma Heart Institute and continue to host external speakers and highlight work from colleagues within HHI and across campus, which has led to many multi-disciplinary discussions and collaborations
Initiated quarterly "Works in Progress" meetings to bring together the seven funded research teams to allow for interaction, sharing ideas, and providing feedback
Revised research curriculum for Clinical Fellows to include interactive didactic platforms to educate trainees in areas of research and formal scientific writing
Leveraged over $5.4M in additional funding, conducted seven presentations, and published 24 manuscripts