Car-T Cell Therapy to Treat Bladder Cancer

Developing an innovative strategy to treat bladder cancer and prevent recurrence and metastasis in Wisconsin

Full Project Name:BCG Boosted CAR-T Cell Therapy to Treat Bladder CancerPrincipal Investigator:Weiguo Cui, PhD, Microbiology and ImmunologyCo-Investigator:William See, MD, Urology; Bryon Johnson, PhD, MedicineAward Amount:$250,000
Award Date
July2020
Project Duration:24 months

Project Description Narrative:


Bladder cancer is not only one of the most common cancers in Wisconsin, it is also difficult to treat and has high rates of recurrence. While recent advances around adoptive cell transfer (ACT) of tumor reactive T cells has been identified as showing remarkable clinical success in treating hematologic malignancies, treating solid tumors such as bladder cancer with this technique has remained a challenge.

Through this award, project investigators will aim to use an innovative strategy to generate robust T cell responses in the bladder and successfully eradicate primary bladder cancer while providing long-term protection from recurrence and metastasis.

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