Building a resource to promote drug discovery research and expedite translational research at the Medical College of Wisconsin
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Developed first Nuclear Magnetic Resonance (NMR) based screening of chemical fragments at MCW, and one of the few in academic medical schools worldwide, positioning the team to significantly enhance research capacity and speed drug discovery research for MCW investigators with promising targets for new drugs
Documented progress toward implementation of a fragment-based drug discovery screening platform that uses recently-acquired specialized instrumentation and is widely applicable to any protein target
Created a drug discovery program to screen chemical libraries against nine proteins with the initial goals of identifying small molecule "hits" to develop into therapeutic compounds to treat infectious diseases, inflammation, cancer and neurodegeneration
Identified small molecules that specifically bind to these proteins, which are implicated in cancer, psoriasis, and diabetes
Developed new, faster computational methods for automatic identification of chemical hits from the chemical library screening, reporting no loss in accuracy
Contributed to eight research studies that have been submitted to NIH resulting in a total of $5.7 million in extramural funding
Conducted 38 presentations and has two publishing efforts underway to disseminate findings from this research
8701 W Watertown Plank Road, Milwaukee, WI 53226-0509 (414) 955-4350
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