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High Throughput Crystallization Robotics

Developing a robotic facility for high-throughput crystallization trials

Full Project Name:High Throughput Crystallization RoboticsPrincipal Investigator:Joseph T Barbieri, PhD, Microbiology & ImmunologyCo-Investigator:Paula Traktman, PhD, Microbiology & Immunology; Ming Lei, PhD, Microbiology & Immunology; William Campbell, PhD, Pharmacology and Toxicology; Jung-Ja Kim, PhD, Biochemistry; Bassam Wakim, PhD, AnesthesiologyAward Amount:$225,000
Award Date
July2004
Project Duration:36 months

Project Description Narrative:


For most investigators, the major “hurdle” in initiating structural studies is the challenge of obtaining crystals of a protein of interest. The “art” of growing protein crystals for structural analysis has not progressed to the state where high-throughput robotic technology can be used to screen a matrix of conditions for their ability to generate crystals suitable for X-ray diffraction. This robotic approach enables even novice investigators to screen several proteins under multiple conditions. The researchers involved in this project seek to purchase an instrumentation system for robotic-based crystallization trials in order to prioritize structural biology as an essential component of contemporary biomedical science at the Medical College of Wisconsin. This technology will provide a platform on which to establish collaborative research efforts between investigators involved in the disciplines of molecular genetics and structural biology.

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