Could an In-Vitro Spectrokinetic Prion-Copper Binding Assay Predict Neurodegenerative Disease?

Project Description Narrative:

This project aims to test the hypothesis that an in vitro predictive test for a predilection to certain neurodegenerative diseases, including Parkinson’s, Wilson’s and Alzheimer’s diseases, can be developed, based on genetic screening for mutations in the prion gene.

Neurodegenerative diseases represent a significant public health problem; about 10,000 Wisconsin residents suffer from Parkinson’s, with 1,000 new cases annually, and almost 90,000 suffer from Alzheimer’s disease or related dementia. Successful development of a predictive test would facilitate early intervention, and advise life planning and genetic counseling, for Wisconsinites found to have a predilection towards idiopathic Parkinsonism, Wilson’s disease, and prion diseases. It is particularly appropriate that this research be carried out in Wisconsin, where a comprehensive infant genetic screening program is already in place.