Control of Vascular and Blood Development by GATA-4

Project Description Narrative:

This study will provide insight into the fundamental mechanisms that control lymphatic vasculature formation and will advance the researchers’ understanding of the processes that go awry in cardiovascular anomalies. In addition, success in the researchers’ proposed aims will significantly advance their understanding of the fundamental processes that govern formation of hematopoietic progenitor cells and the contribution of the stromal environment to this process. Such an understanding could in turn contribute to the development of new procedures to control the rational differentiation and generation of hematopoietic stem cells in culture.