Advanced Nanospray Mass Spectrometer for Proteomic Applications

Project Description Narrative:

The Protein and Nucleic Acid (PNA) Facility was established as an institutional support core at MCW in 1986, since which time the facilities scope has grown to include specialized state-of-the-art services for protein and nucleic acid analysis for over 80 MCW investigators and an equal number from neighboring institutions, institutions across the U.S., and private corporations. It’s affordable and unprecedented service has provided MCW investigators with a competitive edge in their research efforts and grant applications. Proteomic services provided by the facility are increasingly limited by the low sensitivity of its matrix-assisted laser desorption/ionization mass spectrometer. This project seeks funding to purchase a new liquid chromatography/mass spectrometer that will increase the sensitivity of detection by a minimum of 1,000-fold. This cutting-edge technology will provide MCW investigators with a powerful resource to support their research, while giving the PNA the most efficient means of assisting the research efforts of the largest number of investigators at MCW by using a proven mechanism for fee-for-service core support.