Innovative Approaches to Precision Medicine

Advancing understanding of how to measure and account for the influence of environmental and lifestyle factors in precision medicine for common diseases such as hypertension, kidney, and heart disease

Full Project Name:Innovative Approaches to Precision Medicine (IAPM)Principal Investigator:Mingyu Liang, MB, PhD, PhysiologyAward Amount:$1,500,000
Award Date
January2017
Project Duration:60 months

Project Description Narrative:


Recent progress in genomics and big data has led to precision medicine, a new approach for disease prevention and treatment that considers the variability in genes, environment, and lifestyle for each person. Current efforts in precision medicine focus primarily on genome sequences, an approach that could be productive for diseases such as congenital diseases and cancer where a small number of genome sequence variations play a major role in the disease of a patient.

However, genome sequences alone are unlikely to be useful for common diseases such as heart disease, hypertension, and kidney disease due to several factors. Adding to that, environmental and lifestyle factors greatly influence these diseases. The role of environmental and lifestyle factors has been largely neglected in precision medicine.

Through this award, investigators aim to use innovative approaches to advance precision medicine's understanding of how to measure and account for the influence of environmental and lifestyle factors, and facilitate individualized care for patients with common diseases such as hypertension, kidney, and heart disease.

Project Updates:


• Began developing and improving several highly complex research methods that will be essential to the program

• Obtained and analyzed several research samples, submitting appropriate requests to the Institutional Review Board to recruit additional subjects

• Contributed to several publications in top specialty journals, providing broad recognition of ideas that will benefit the health of Wisconsin residents

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